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Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast

Most long non-coding RNAs (lncRNAs) encoded by eukaryotic genomes remain uncharacterized. Here we focus on a set of intergenic lncRNAs in fission yeast. Deleting one of these lncRNAs exhibited a clear phenotype: drug sensitivity. Detailed analyses of the affected locus revealed that transcription of...

詳細記述

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書誌詳細
出版年:Nat Commun
主要な著者: Ard, Ryan, Tong, Pin, Allshire, Robin C.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Pub. Group 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255232/
https://ncbi.nlm.nih.gov/pubmed/25428589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6576
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