Structural Identification of Modified Amino Acids on the Interface between EPO and Its Receptor from EPO BRP, Human Recombinant Erythropoietin by LC/MS Analysis

Protein modifications of recombinant pharmaceuticals have been observed both in vitro and in vivo. These modifications may result in lower efficacy, as well as bioavailability changes and antigenicity among the protein pharmaceuticals. Therefore, the contents of modification should be monitored for...

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Veröffentlicht in:Mol Cells
Hauptverfasser: Song, Kwang-Eun, Byeon, Jaehee, Moon, Dae-Bong, Kim, Hyong-Ha, Choi, Yoo-Joo, Suh, Jung-Keun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Society for Molecular and Cellular Biology 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255102/
https://ncbi.nlm.nih.gov/pubmed/25284312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2014.0214
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