External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1

The cell-impermeant lidocaine derivative QX-314 blocks sodium channels via intracellular mechanisms. In somatosensory nociceptive neurons, open transient receptor potential vanilloid type 1 (TRPV1) receptors provide a transmembrane passageway for QX-314 to produce long-lasting analgesia. Many crania...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurophysiol
Prif Awduron: Hofmann, Mackenzie E., Largent-Milnes, Tally M., Fawley, Jessica A., Andresen, Michael C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2014
Pynciau:
Neural Circuits
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254884/
https://ncbi.nlm.nih.gov/pubmed/25185814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00316.2014
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