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External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1
The cell-impermeant lidocaine derivative QX-314 blocks sodium channels via intracellular mechanisms. In somatosensory nociceptive neurons, open transient receptor potential vanilloid type 1 (TRPV1) receptors provide a transmembrane passageway for QX-314 to produce long-lasting analgesia. Many crania...
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| Udgivet i: | J Neurophysiol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254884/ https://ncbi.nlm.nih.gov/pubmed/25185814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00316.2014 |
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