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ALLOSTERY AND SUBSTRATE CHANNELING IN THE TRYPTOPHAN SYNTHASE BIENZYME COMPLEX: EVIDENCE FOR TWO SUBUNIT CONFORMATIONS AND FOUR QUATERNARY STATES

The allosteric regulation of substrate channeling in tryptophan synthase involves ligand-mediated allosteric signaling that switches the α- and β-subunits between open (low activity) and closed (high activity) conformations. This switching prevents the escape of the common intermediate, indole, and...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Niks, Dimitri, Hilario, Eduardo, Dierkers, Adam, Ngo, Huu, Borchardt, Dan, Neubauer, Thomas J., Fan, Li, Mueller, Leonard J., Dunn, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254854/
https://ncbi.nlm.nih.gov/pubmed/23952479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400795e
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