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The effect of adjuvanting cancer vaccines with herpes simplex virus glycoprotein D on melanoma-driven CD8(+) T cell exhaustion()
Two vaccines expressing CD4(+) and CD8(+) T cell epitopes of MAAs by a chimpanzee-derived replication-defective AdC68 vector were compared in a mouse model of melanoma. In one vaccine, termed AdC68-gDMelapoly, the epitopes were expressed as a fusion protein within HSV-1 gD, which blocks immunoinhibi...
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| Vydáno v: | J Immunol |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254702/ https://ncbi.nlm.nih.gov/pubmed/25024391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302029 |
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