Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling

Central serotonin (5-HT) modulates somatosensory transduction, but how it achieves sensory modality-specific modulation remains unclear. Here we report that enhancing serotonergic tone via administration of 5-hydroxytryptophan potentiates itch sensation, whereas mice lacking 5-HT or serotonergic neu...

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Published in:Neuron
Main Authors: Zhao, Zhong-Qiu, Liu, Xian-Yu, Jeffry, Joseph, Karunarathne, W.K. Ajith, Li, Jin-Lian, Munanairi, Admire, Zhou, Xuan-Yi, Li, Hui, Sun, Yan-Gang, Wan, Li, Wu, Zhen-Yu, Kim, Seungil, Huo, Fu-Quan, Mo, Ping, Barry, Devin M, Zhang, Chun-Kui, Kim, Ji-Young, Gautam, N., Renner, Kenneth J., Li, Yun-Qing, Chen, Zhou-Feng
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254557/
https://ncbi.nlm.nih.gov/pubmed/25453842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.10.003
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