Unidirectional Cross-activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids

Why do opiates make human beings itch ? Spinal opioid-induced itch, a prevalent side effect of pain management, has been considered to occur as a result of pain inhibition. We report that morphine-induced scratching (MIS) is abolished in mice lacking either gastrin-releasing peptide receptor (GRPR)...

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Huvudupphovsmän: Liu, Xian-Yu, Liu, Zhong-Chun, Sun, Yan-Gang, Ross, Michael, Kim, Seungil, Tsai, Feng-Fang, Li, Qi-Fang, Jeffry, Joseph, Kim, Ji-Young, Loh, Horace H., Chen, Zhou-Feng
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197217/
https://ncbi.nlm.nih.gov/pubmed/22000021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.08.043
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