Oral Administration of a Fusion Protein between the Cholera Toxin B Subunit and the 42-Amino Acid Isoform of Amyloid-β Peptide Produced in Silkworm Pupae Protects against Alzheimer's Disease in Mice

A key molecule in the pathogenesis of Alzheimer's disease (AD) is a 42-amino acid isoform of the amyloid-β peptide (Aβ42), which is the most toxic element of senile plaques. In this study, to develop an edible, safe, low-cost vaccine for AD, a cholera toxin B subunit (CTB)-Aβ42 fusion protein w...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Li, Si, Wei, Zhen, Chen, Jian, Chen, Yanhong, Lv, Zhengbing, Yu, Wei, Meng, Qiaohong, Jin, Yongfeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254457/
https://ncbi.nlm.nih.gov/pubmed/25469702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113585
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