Impact of Acamprosate on Plasma Amyloid-β Precursor Protein in Youth: A Pilot Analysis in Fragile X Syndrome-Associated and Idiopathic Autism Spectrum Disorder Suggests a Pharmacodynamic Protein Marker

BACKGROUND: Understanding of the pathophysiology of autism spectrum disorder (ASD) remains limited. Brain overgrowth has been hypothesized to be associated with the development of ASD. A derivative of amyloid-β precursor protein (APP), secreted APPα (sAPPα), has neuroproliferative effects and has be...

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Udgivet i:J Psychiatr Res
Main Authors: Erickson, Craig A., Ray, Balmiki, Maloney, Bryan, Wink, Logan K., Bowers, Katherine, Schaefer, Tori L., McDougle, Christopher J., Sokol, Deborah K., Lahiri, Debomoy K.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253657/
https://ncbi.nlm.nih.gov/pubmed/25300441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpsychires.2014.07.011
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