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Epistasis Between Polymorphisms in COMT, ESR1, and GCH1 Influences COMT Enzyme Activity and Pain

Abnormalities in the enzymatic activity of catechol-O-methyltransferase (COMT) contribute to chronic pain conditions, such as temporomandibular disorders (TMD). Thus, we sought to determine the effects of polymorphisms in COMT and functionally-related pain genes in the COMT pathway (estrogen recepto...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Smith, Shad B., Reenilä, Ilkka, Männistö, Pekka T., Slade, Gary D., Maixner, William, Diatchenko, Luda, Nackley, Andrea G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253645/
https://ncbi.nlm.nih.gov/pubmed/25218601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2014.09.009
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