Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers

BACKGROUND: Methylation of the MLH1 promoter region has been suggested to be a major mechanism of gene inactivation in sporadic microsatellite instability-positive (MSI-H) colorectal cancers (CRCs). Recently, single-nucleotide polymorphism (SNP) in the MLH1 promoter region (MLH1-93G/A; rs1800734) ha...

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Vydáno v:BMC Res Notes
Hlavní autoři: Miyakura, Yasuyuki, Tahara, Makiko, Lefor, Alan T, Yasuda, Yoshikazu, Sugano, Kokichi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253604/
https://ncbi.nlm.nih.gov/pubmed/25421847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-835
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