Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export

Leucine-rich repeat kinase 2 (LRRK2) has been associated with Parkinson’s disease (PD) and other disorders. However, its normal physiological functions and pathogenic properties remain elusive. Here we show that LRRK2 regulates the anterograde ER–Golgi transport through anchoring Sec16A at the endop...

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Udgivet i:EMBO J
Main Authors: Cho, Hyun Jin, Yu, Jia, Xie, Chengsong, Rudrabhatla, Parvathi, Chen, Xi, Wu, Junbing, Parisiadou, Loukia, Liu, Guoxiang, Sun, Lixin, Ma, Bo, Ding, Jinhui, Liu, Zhihua, Cai, Huaibin
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253522/
https://ncbi.nlm.nih.gov/pubmed/25201882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201487807
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