P2Y(2)R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment

Tumor microenvironmental hypoxia induces hypoxia inducible factor-1α (HIF-1α) overexpression, leading to the release of lysyl oxidase (LOX), which crosslinks collagen at distant sites to facilitate environmental changes that allow cancer cells to easily metastasize. Our previous study showed that ac...

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Vydáno v:Oncotarget
Hlavní autoři: Joo, Young Nak, Jin, Hana, Eun, So Young, Park, Sang Won, Chang, Ki Churl, Kim, Hye Jung
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253437/
https://ncbi.nlm.nih.gov/pubmed/25238333
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