Decreased methionine synthesis in purine nucleoside-treated T and B lymphoblasts and reversal by homocysteine.

Purine nucleosides, which accumulate in adenosine deaminase and purine nucleoside phosphorylase deficiency, are toxic to lymphoid cells. Since adenine nucleosides inhibit S-adenosylhomocysteine hydrolase, they could potentially decrease intracellular methionine synthesis. To test this hypothesis, we...

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Pubblicato in:	J Clin Invest
Autori principali:	Boss, G R, Pilz, R B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425293/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6332827/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111536
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