Metformin exaggerates phenylephrine-induced AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in endothelium-denuded rat aorta

Metformin, a widely prescribed antidiabetic drug, has been shown to reduce the risk of cardiovascular disease, including hypertension. Its beneficial effect toward improved vasodilation results from its ability to activate AMPK and enhance nitric oxide formation in the endothelium. To date, metformi...

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Pubblicato in:Biochem Pharmacol
Autori principali: Pyla, Rajkumar, Osman, Islam, Pichavaram, Prahalathan, Hansen, Paul, Segar, Lakshman
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252840/
https://ncbi.nlm.nih.gov/pubmed/25179145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.08.024
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