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Metformin exaggerates phenylephrine-induced AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in endothelium-denuded rat aorta

Metformin, a widely prescribed antidiabetic drug, has been shown to reduce the risk of cardiovascular disease, including hypertension. Its beneficial effect toward improved vasodilation results from its ability to activate AMPK and enhance nitric oxide formation in the endothelium. To date, metformi...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Biochem Pharmacol
Main Authors: Pyla, Rajkumar, Osman, Islam, Pichavaram, Prahalathan, Hansen, Paul, Segar, Lakshman
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252840/
https://ncbi.nlm.nih.gov/pubmed/25179145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.08.024
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