MHC-restricted phosphopeptides derived from Insulin receptor substrate-2 and CDC25b offer broad-based immunotherapeutic agents for cancer

Cancer cells display novel phosphopeptides in association with MHC class I and II molecules. In this study, we evaluated two HLA-A2-restricted phosphopeptides derived from the insulin receptor substrate (IRS)-2 and the cell cycle regulator CDC25b. These proteins are both broadly expressed in multipl...

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Publicado no:Cancer Res
Main Authors: Zarling, Angela L., Obeng, Rebecca C., Desch, A. Nicole, Pinczewski, Joel, Cummings, Kara L., Deacon, Donna H., Conaway, Mark, Slingluff, Craig L., Engelhard, Victor H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252710/
https://ncbi.nlm.nih.gov/pubmed/25297629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0043
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