ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase I inhibitors by disabling DNA replication initiation and fork elongation responses

Camptothecin and its derivatives, topotecan and irinotecan are specific topoisomerase I (Top1) inhibitors and potent anticancer drugs killing cancer cells by producing replication-associated DNA double-strand breaks, and the indenoisoquinoline LMP-400 (indotecan) is a novel Top1 inhibitor in clinica...

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Foilsithe in:Cancer Res
Main Authors: Jossé, Rozenn, Martin, Scott E., Guha, Rajarshi, Ormanoglu, Pinar, Pfister, Thomas D., Reaper, Philip M., Barnes, Christopher S., Jones, Julie, Charlton, Peter, Pollard, John R., Morris, Joel, Doroshow, James H., Pommier, Yves
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252598/
https://ncbi.nlm.nih.gov/pubmed/25269479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3369
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