Mechanisms of fever induced by recombinant human interferon.

Since the early trials using human interferon (hIFN) derived from blood leukocytes or cell lines, fever has been a prominent component of IFN therapy. Human protein impurities might account for the fever to cell-derived hIFN, but recombinant hIFN, free of extraneous human proteins, has produced feve...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Dinarello, C A, Bernheim, H A, Duff, G W, Le, H V, Nagabhushan, T L, Hamilton, N C, Coceani, F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1984
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6590569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111508
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