RORγt, but not T-bet, Overexpression Exacerbates an Autoimmune Model for Multiple Sclerosis

Th17 cells play an important role in multiple sclerosis (MS) and its autoimmune model, experimental autoimmune encephalomyelitis (EAE). However, studies have not addressed how enhanced Th17 immune responses can affect demyelinating diseases. We induced EAE with MOG in RORγt transgenic C57BL/6 mice t...

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Bibliographic Details
Published in:J Neuroimmunol
Main Authors: Martinez, Nicholas E., Sato, Fumitaka, Omura, Seiichi, Kawai, Eiichiro, Takahashi, Satoru, Yoh, Keigyou, Tsunoda, Ikuo
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252371/
https://ncbi.nlm.nih.gov/pubmed/25288300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2014.09.006
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