Deficiency of the iron-sulfur clusters of mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase (complex I) in an infant with congenital lactic acidosis.

We report the case of an infant with hypoglycemia, progressive lactic acidosis, an increased serum lactate/pyruvate ratio, and elevated plasma alanine, who had a moderate to profound decrease in the ability of mitochondria from four organs to oxidize pyruvate, malate plus glutamate, citrate, and oth...

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Pubblicato in:	J Clin Invest
Autori principali:	Moreadith, R W, Batshaw, M L, Ohnishi, T, Kerr, D, Knox, B, Jackson, D, Hruban, R, Olson, J, Reynafarje, B, Lehninger, A L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425222/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6432847/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111484
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