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Deficiency of the iron-sulfur clusters of mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase (complex I) in an infant with congenital lactic acidosis.

We report the case of an infant with hypoglycemia, progressive lactic acidosis, an increased serum lactate/pyruvate ratio, and elevated plasma alanine, who had a moderate to profound decrease in the ability of mitochondria from four organs to oxidize pyruvate, malate plus glutamate, citrate, and oth...

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Bibliografiske detaljer
Main Authors: Moreadith, R W, Batshaw, M L, Ohnishi, T, Kerr, D, Knox, B, Jackson, D, Hruban, R, Olson, J, Reynafarje, B, Lehninger, A L
Format: Artigo
Sprog:Inglês
Udgivet: 1984
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC425222/
https://ncbi.nlm.nih.gov/pubmed/6432847
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