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Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

Ceramide, a lipid mediator, has been most closely associated with antiproliferative activities. In this study, we examine the mechanism by which ceramide induces growth suppression and the role of the retinoblastoma gene product (Rb) in this process. Withdrawal of serum from the serum-dependent MOLT...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Dbaibo, G S, Pushkareva, M Y, Jayadev, S, Schwarz, J K, Horowitz, J M, Obeid, L M, Hannun, Y A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42516/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7877980/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.5.1347
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