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Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

A disruptive approach to therapeutic discovery and development is required in order to significantly improve the success rate of drug discovery for central nervous system (CNS) disorders. In this review, we first assess the key factors contributing to the frequent clinical failures for novel drugs....

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Schadt, Eric E., Buchanan, Sean, Brennand, Kristen J., Merchant, Kalpana M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251289/
https://ncbi.nlm.nih.gov/pubmed/25520658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00252
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