IDRdecoder: a machine learning approach for rational drug discovery toward intrinsically disordered regions

IntroductionIntrinsically disordered regions (IDRs) of proteins have traditionally been overlooked as drug targets. However, with growing recognition of their crucial role in biological activity and their involvement in various diseases, IDRs have emerged as promising targets for drug discovery. Des...

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Autors principals: Clara Shionyu-Mitusyama, Satoshi Ohmori, Subaru Hirata, Hirokazu Ishida, Tsuyoshi Shirai
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2025-07-01
Col·lecció:Frontiers in Bioinformatics
Matèries:
intrinsically disordered proteins
neural net
sequence-based prediction method
structural bioinformatics
drug design
Accés en línia:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1627836/full
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