Epigenetic Events Determine Tissue-Specific Toxicity of Inhalational Exposure to the Genotoxic Chemical 1,3-Butadiene in Male C57BL/6J Mice

1,3-Butadiene (BD), a widely used industrial chemical and a ubiquitous environmental pollutant, is a known human carcinogen. Although genotoxicity is an established mechanism of the tumorigenicity of BD, epigenetic effects have also been observed in livers of mice exposed to the chemical. To better...

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Detalles Bibliográficos
Publicado en:Toxicol Sci
Main Authors: Chappell, Grace, Kobets, Tetyana, O’Brien, Bridget, Tretyakova, Natalia, Sangaraju, Dewakar, Kosyk, Oksana, Sexton, Kenneth G., Bodnar, Wanda, Pogribny, Igor P., Rusyn, Ivan
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
1,3-Butadiene Toxicity Mediated by Epigenetic Alterations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250847/
https://ncbi.nlm.nih.gov/pubmed/25237060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu191
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