A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia

We have identified a novel 7.7 Mb del(8)(q23.2q24.11) in a patient progressing to acute myeloid leukemia (AML) following a 12-year stable phase of chronic myelomonocytic leukemia (CMML). A surprisingly high JAK2+ allelic burden of 92% at the time of AML led us to delineate the molecular aberrations...

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Detalles Bibliográficos
Publicado en:Leuk Res Rep
Autores principales: Toft-Petersen, Marie, Kjeldsen, Eigil, Nederby, Line, Grønbæk, Kirsten, Hokland, Peter, Roug, Anne Stidsholt
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2014
Materias:
Case Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250842/
https://ncbi.nlm.nih.gov/pubmed/25473623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2014.09.002
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