A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia

We have identified a novel 7.7 Mb del(8)(q23.2q24.11) in a patient progressing to acute myeloid leukemia (AML) following a 12-year stable phase of chronic myelomonocytic leukemia (CMML). A surprisingly high JAK2+ allelic burden of 92% at the time of AML led us to delineate the molecular aberrations...

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Detalhes bibliográficos
Publicado no:Leuk Res Rep
Main Authors: Toft-Petersen, Marie, Kjeldsen, Eigil, Nederby, Line, Grønbæk, Kirsten, Hokland, Peter, Roug, Anne Stidsholt
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250842/
https://ncbi.nlm.nih.gov/pubmed/25473623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2014.09.002
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