Expression and immunoactivity of chimeric particulate antigens of receptor binding site-core antigen of hepatitis B virus

AIM: To improve the immunogenicity of receptor binding site of hepatitis B virus (HBV) on preS1 antigen using HBV core antigen as an immuno-carrier. METHODS: One to 6 tandem copies of HBV preS1 (21-47) fragment were inserted into HBcAg at the sites of aa 78 and 82, and expressed in E.coli. ELISA, We...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Yang, Hai-Jie, Chen, Min, Cheng, Tong, He, Shui-Zhen, Li, Shao-Wei, Guan, Bao-Quan, Zhu, Zi -Heng, Gu, Ying, Zhang, Jun, Xia, Ning-Shao
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2005
Assuntos:
Viral Hepatitis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250797/
https://ncbi.nlm.nih.gov/pubmed/15641132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i4.492
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