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Upstream Open Reading Frame in 5′-Untranslated Region Reduces Titin mRNA Translational Efficiency

Titin is the largest known protein and a critical determinant of myofibril elasticity and sarcomere structure in striated muscle. Accumulating evidence that mRNA transcripts are post-transcriptionally regulated by specific motifs located in the flanking untranslated regions (UTRs) led us to consider...

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Publicat a:Biochem Biophys Res Commun
Autors principals: Cadar, Adrian G., Zhong, Lin, Lin, Angel, Valenzuela, Mauricio, Lim, Chee C.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250383/
https://ncbi.nlm.nih.gov/pubmed/25264194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.09.085
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