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Physical evidence for distinct mechanisms of translational control by upstream open reading frames

The Saccharomyces cerevisiae GCN4 mRNA 5′-leader contains four upstream open reading frames (uORFs) and the CPA1 leader contains a single uORF. To determine how these uORFs control translation, we examined mRNAs containing these leaders in cell-free translation extracts to determine where ribosomes...

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Autors principals: Gaba, Anthony, Wang, Zhong, Krishnamoorthy, Thanuja, Hinnebusch, Alan G., Sachs, Matthew S.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC125715/
https://ncbi.nlm.nih.gov/pubmed/11707416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.22.6453
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