Physical evidence for distinct mechanisms of translational control by upstream open reading frames

The Saccharomyces cerevisiae GCN4 mRNA 5′-leader contains four upstream open reading frames (uORFs) and the CPA1 leader contains a single uORF. To determine how these uORFs control translation, we examined mRNAs containing these leaders in cell-free translation extracts to determine where ribosomes...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Gaba, Anthony, Wang, Zhong, Krishnamoorthy, Thanuja, Hinnebusch, Alan G., Sachs, Matthew S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125715/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707416/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6453
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