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A fine balance: regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging

Memory decline is a common feature of aging. Expression of the immediate-early gene Arc is necessary for normal long-term memory, and although experience dependent Arc transcription is reportedly reduced in the aged rat hippocampus, it has not been clear whether this effect is an invariant consequen...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Learn Mem
Prif Awduron: Fletcher, Bonnie R., Hill, Gordon S., Long, Jeffrey M., Gallagher, Michela, Shapiro, Matthew L., Rapp, Peter R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250373/
https://ncbi.nlm.nih.gov/pubmed/25151943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nlm.2014.08.007
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