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Wild Type RTA and Less Toxic Variants Have Distinct Requirements for Png1 for Their Depurination Activity and Toxicity in Saccharomyces cerevisiae

Ricin A chain (RTA) undergoes retrograde trafficking and is postulated to use components of the endoplasmic reticulum (ER) associated degradation (ERAD) pathway to enter the cytosol to depurinate ribosomes. However, it is not known how RTA evades degradation by the proteasome after entry into the cy...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yan, Qing, Li, Xiao-Ping, Tumer, Nilgun E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250064/
https://ncbi.nlm.nih.gov/pubmed/25436896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113719
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