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Interface Matters: The Stiffness Route to Stability of a Thermophilic Tetrameric Malate Dehydrogenase

In this work we investigate by computational means the behavior of two orthologous bacterial proteins, a mesophilic and a thermophilic tetrameric malate dehydrogenase (MalDH), at different temperatures. Namely, we quantify how protein mechanical rigidity at different length- and time-scales correlat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kalimeri, Maria, Girard, Eric, Madern, Dominique, Sterpone, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250060/
https://ncbi.nlm.nih.gov/pubmed/25437494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113895
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