G-Quadruplex Structures and CpG Methylation Cause Drop-Out of the Maternal Allele in Polymerase Chain Reaction Amplification of the Imprinted MEST Gene Promoter

We observed apparent non-Mendelian behaviour of alleles when genotyping a region in a CpG island at the 5′ end of the maternally imprinted human MEST isoform. This region contains three single nucleotide polymorphisms (SNPs) in total linkage disequilibrium, such that only two haplotypes occur in the...

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Vydáno v:PLoS One
Hlavní autoři: Stevens, Aaron J., Stuffrein-Roberts, Selma, Cree, Simone L., Gibb, Andrew, Miller, Allison L., Doudney, Kit, Aitchison, Alan, Eccles, Michael R., Joyce, Peter R., Filichev, Vyacheslav V., Kennedy, Martin A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249981/
https://ncbi.nlm.nih.gov/pubmed/25437198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113955
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