Immunosuppression by D-penicillamine in vitro. Inhibition of human T lymphocyte proliferation by copper- or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes.
It has been suggested that D-penicillamine is active in rheumatoid arthritis because of its capacity to function as a selective inhibitor of T lymphocyte function. The basis for the immunosuppressive action of this drug as well as mechanisms whereby the effect of D-penicillamine could be modified by...
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| Published in: | J Clin Invest |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1984
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424970/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6606652/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111207 |
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