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Immunosuppression by D-penicillamine in vitro. Inhibition of human T lymphocyte proliferation by copper- or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes.
It has been suggested that D-penicillamine is active in rheumatoid arthritis because of its capacity to function as a selective inhibitor of T lymphocyte function. The basis for the immunosuppressive action of this drug as well as mechanisms whereby the effect of D-penicillamine could be modified by...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1984
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC424970/ https://ncbi.nlm.nih.gov/pubmed/6606652 |
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