NS5A Inhibitors Impair NS5A–Phosphatidylinositol 4-Kinase IIIα Complex Formation and Cause a Decrease of Phosphatidylinositol 4-Phosphate and Cholesterol Levels in Hepatitis C Virus-Associated Membranes

The hepatitis C virus (HCV) nonstructural (NS) protein 5A is a multifunctional protein that plays a central role in viral replication and assembly. Antiviral agents directly targeting NS5A are currently in clinical development. Although the elucidation of the mechanism of action (MOA) of NS5A inhibi...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Reghellin, V., Donnici, L., Fenu, S., Berno, V., Calabrese, V., Pagani, M., Abrignani, S., Peri, F., De Francesco, R., Neddermann, P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249536/
https://ncbi.nlm.nih.gov/pubmed/25224012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03293-14
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