Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

4-anilino quinazolines have been identified as inhibitors of HCV replication. The target of this class of compounds was proposed to be the viral protein NS5A, although unequivocal proof has never been presented. A 4-anilino quinazoline moiety is often found in kinase inhibitors, leading us to formul...

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Detalhes bibliográficos
Main Authors: Bianco, Annalisa, Reghellin, Veronica, Donnici, Lorena, Fenu, Simone, Alvarez, Reinaldo, Baruffa, Chiara, Peri, Francesco, Pagani, Massimiliano, Abrignani, Sergio, Neddermann, Petra, De Francesco, Raffaele
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297592/
https://ncbi.nlm.nih.gov/pubmed/22412376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002576
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