Use of Immunodampening To Overcome Diversity in the Malarial Vaccine Candidate Apical Membrane Antigen 1

Apical membrane antigen 1 (AMA1) is a leading malarial vaccine candidate; however, its polymorphic nature may limit its success in the field. This study aimed to circumvent AMA1 diversity by dampening the antibody response to the highly polymorphic loop Id, previously identified as a major target of...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Harris, Karen S., Adda, Christopher G., Khore, Madhavi, Drew, Damien R., Valentini-Gatt, Antonina, Fowkes, Freya J. I., Beeson, James G., Dutta, Sheetij, Anders, Robin F., Foley, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249334/
https://ncbi.nlm.nih.gov/pubmed/25156737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02061-14
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