A Synthetic Peptide Corresponding to the Extracellular Loop 2 Region of Claudin-4 Protects against Clostridium perfringens Enterotoxin In Vitro and In Vivo

Clostridium perfringens enterotoxin (CPE) action starts when the toxin binds to claudin receptors. Claudins contain two extracellular loop domains, with the second loop (ECL-2) being slightly smaller than the first. CPE has been shown to bind to ECL-2 in receptor claudins. We recently demonstrated t...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Shrestha, Archana, Robertson, Susan L., Garcia, Jorge, Beingasser, Juliann, McClane, Bruce A., Uzal, Francisco A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Bacterial Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249305/
https://ncbi.nlm.nih.gov/pubmed/25156725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02453-14
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