A Synthetic Peptide Corresponding to the Extracellular Loop 2 Region of Claudin-4 Protects against Clostridium perfringens Enterotoxin In Vitro and In Vivo

Clostridium perfringens enterotoxin (CPE) action starts when the toxin binds to claudin receptors. Claudins contain two extracellular loop domains, with the second loop (ECL-2) being slightly smaller than the first. CPE has been shown to bind to ECL-2 in receptor claudins. We recently demonstrated t...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Shrestha, Archana, Robertson, Susan L., Garcia, Jorge, Beingasser, Juliann, McClane, Bruce A., Uzal, Francisco A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Bacterial Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249305/
https://ncbi.nlm.nih.gov/pubmed/25156725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02453-14
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