A Synthetic Peptide Corresponding to the Extracellular Loop 2 Region of Claudin-4 Protects against Clostridium perfringens Enterotoxin In Vitro and In Vivo

Clostridium perfringens enterotoxin (CPE) action starts when the toxin binds to claudin receptors. Claudins contain two extracellular loop domains, with the second loop (ECL-2) being slightly smaller than the first. CPE has been shown to bind to ECL-2 in receptor claudins. We recently demonstrated t...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Shrestha, Archana, Robertson, Susan L., Garcia, Jorge, Beingasser, Juliann, McClane, Bruce A., Uzal, Francisco A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249305/
https://ncbi.nlm.nih.gov/pubmed/25156725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02453-14
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