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Cyclic AMP-Mediated Suppression of Neutrophil Extracellular Trap Formation and Apoptosis by the Bordetella pertussis Adenylate Cyclase Toxin

The adenylate cyclase toxin (ACT) of Bordetella pertussis intoxicates target cells by generating supraphysiologic levels of intracellular cyclic AMP (cAMP). Since ACT kills macrophages rapidly and potently, we asked whether ACT would also kill neutrophils. In fact, ACT prolongs the neutrophil life s...

詳細記述

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書誌詳細
出版年:Infect Immun
主要な著者: Eby, Joshua C., Gray, Mary C., Hewlett, Erik L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249293/
https://ncbi.nlm.nih.gov/pubmed/25287922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02487-14
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