Cyclic AMP-Mediated Suppression of Neutrophil Extracellular Trap Formation and Apoptosis by the Bordetella pertussis Adenylate Cyclase Toxin

The adenylate cyclase toxin (ACT) of Bordetella pertussis intoxicates target cells by generating supraphysiologic levels of intracellular cyclic AMP (cAMP). Since ACT kills macrophages rapidly and potently, we asked whether ACT would also kill neutrophils. In fact, ACT prolongs the neutrophil life s...

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Detaylı Bibliyografya
Yayımlandı:Infect Immun
Asıl Yazarlar: Eby, Joshua C., Gray, Mary C., Hewlett, Erik L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249293/
https://ncbi.nlm.nih.gov/pubmed/25287922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02487-14
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