Site-Specific Mutation of the Sensor Kinase GraS in Staphylococcus aureus Alters the Adaptive Response to Distinct Cationic Antimicrobial Peptides

The Staphylococcus aureus two-component regulatory system, GraRS, is involved in resistance to killing by distinct host defense cationic antimicrobial peptides (HD-CAPs). It is believed to regulate downstream target genes such as mprF and dltABCD to modify the S. aureus surface charge. However, the...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Cheung, Ambrose L., Bayer, Arnold S., Yeaman, Michael R., Xiong, Yan Q., Waring, Alan J., Memmi, Guido, Donegan, Niles, Chaili, Siyang, Yang, Soo-Jin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249274/
https://ncbi.nlm.nih.gov/pubmed/25287929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02480-14
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