Latency-Associated Viral Interleukin-10 (IL-10) Encoded by Human Cytomegalovirus Modulates Cellular IL-10 and CCL8 Secretion during Latent Infection through Changes in the Cellular MicroRNA hsa-miR-92a

The UL111A gene of human cytomegalovirus encodes a viral homologue of the cellular immunomodulatory cytokine interleukin 10 (cIL-10), which, due to alternative splicing, results in expression of two isoforms designated LAcmvIL-10 (expressed during both lytic and latent infection) and cmvIL-10 (ident...

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Vydáno v:J Virol
Hlavní autoři: Poole, Emma, Avdic, Selmir, Hodkinson, Jemima, Jackson, Sarah, Wills, Mark, Slobedman, Barry, Sinclair, John
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249158/
https://ncbi.nlm.nih.gov/pubmed/25253336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02424-14
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