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A Histidine Residue of the Influenza Virus Hemagglutinin Controls the pH Dependence of the Conformational Change Mediating Membrane Fusion

The conformational change of the influenza virus hemagglutinin (HA) protein mediating the fusion between the virus envelope and the endosomal membrane was hypothesized to be induced by protonation of specific histidine residues since their pK(a)s match the pHs of late endosomes (pK(a) of ∼6.0). Howe...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Mair, Caroline M., Meyer, Tim, Schneider, Katjana, Huang, Qiang, Veit, Michael, Herrmann, Andreas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249083/
https://ncbi.nlm.nih.gov/pubmed/25187542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01704-14
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