Epitope Mapping of the Hemagglutinin Molecule of A/(H1N1)pdm09 Influenza Virus by Using Monoclonal Antibody Escape Mutants

We determined the antigenic structure of pandemic influenza A(H1N1)pdm09 virus hemagglutinin (HA) using 599 escape mutants that were selected using 16 anti-HA monoclonal antibodies (MAbs) against A/Narita/1/2009. The sequencing of mutant HA genes revealed 43 amino acid substitutions at 24 positions...

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Bibliographic Details
Published in:J Virol
Main Authors: Matsuzaki, Yoko, Sugawara, Kanetsu, Nakauchi, Mina, Takahashi, Yoshimasa, Onodera, Taishi, Tsunetsugu-Yokota, Yasuko, Matsumura, Takayuki, Ato, Manabu, Kobayashi, Kazuo, Shimotai, Yoshitaka, Mizuta, Katsumi, Hongo, Seiji, Tashiro, Masato, Nobusawa, Eri
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248900/
https://ncbi.nlm.nih.gov/pubmed/25122788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01381-14
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