Epitope Mapping of the Hemagglutinin Molecule of A/(H1N1)pdm09 Influenza Virus by Using Monoclonal Antibody Escape Mutants

We determined the antigenic structure of pandemic influenza A(H1N1)pdm09 virus hemagglutinin (HA) using 599 escape mutants that were selected using 16 anti-HA monoclonal antibodies (MAbs) against A/Narita/1/2009. The sequencing of mutant HA genes revealed 43 amino acid substitutions at 24 positions...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Matsuzaki, Yoko, Sugawara, Kanetsu, Nakauchi, Mina, Takahashi, Yoshimasa, Onodera, Taishi, Tsunetsugu-Yokota, Yasuko, Matsumura, Takayuki, Ato, Manabu, Kobayashi, Kazuo, Shimotai, Yoshitaka, Mizuta, Katsumi, Hongo, Seiji, Tashiro, Masato, Nobusawa, Eri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248900/
https://ncbi.nlm.nih.gov/pubmed/25122788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01381-14
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