Transmembrane Adaptor Protein PAG/CBP Is Involved in both Positive and Negative Regulation of Mast Cell Signaling

The transmembrane adaptor protein PAG/CBP (here, PAG) is expressed in multiple cell types. Tyrosine-phosphorylated PAG serves as an anchor for C-terminal SRC kinase, an inhibitor of SRC-family kinases. The role of PAG as a negative regulator of immunoreceptor signaling has been examined in several m...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Draberova, Lubica, Bugajev, Viktor, Potuckova, Lucie, Halova, Ivana, Bambouskova, Monika, Polakovicova, Iva, Xavier, Ramnik J., Seed, Brian, Draber, Petr
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248753/
https://ncbi.nlm.nih.gov/pubmed/25246632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00983-14
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